PORPHYRIN RING SOURCE CAN ALTER THE OUTER-MEMBRANE PROTEIN PROFILE OF NONTYPABLE HAEMOPHILUS-INFLUENZAE

被引：8

作者：

MACIVER, I ^{[1
]}

OREILLY, T ^{[1
]}

BROWN, MRW ^{[1
]}

机构：

[1] UNIV ASTON,INST PHARMACEUT SCI,MICROBIOL RES GRP,BIRMINGHAM B4 7ET,W MIDLANDS,ENGLAND

来源：

JOURNAL OF MEDICAL MICROBIOLOGY | 1990年 / 31卷 / 03期

关键词：

D O I：

10.1099/00222615-31-3-163

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Porphyrin ring source appears to alter the outer membrane protein (OMP) profile of some, but not all, non-typable (NT) Haemophilus influenzae strains isolated from sputum. When haemin was replaced with protoporphyrin IX, 41% of strains examined produced increased amounts of a polypeptide of 84 Kda and new OMPs of either 120 or 150 Kda. Immunoblotting with paired patient's sera revealed that antibodies reactive with these proteins were present, demonstrating OMP antigenicity and expression in vivo and indicating that these isolates of NT H. influenzae may display an altered OMP phenotype when growing in the human lung.

引用

页码：163 / 168

页数：6

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