OLIGOMERIC FLAVAN-3-OLS FROM MEDICINAL WILLOW BARK

被引：21

作者：

KOLODZIEJ, H

机构：

[1] Institut für Pharmazeutische Biologie, Phytochemie der Westfälischen Wilhelms-Universität

来源：

PHYTOCHEMISTRY | 1990年 / 29卷 / 03期

关键词：

!sup]1[!/sup]H shift parameters; flavan-3-ols; procyanidins; Salicaceae; Salix spp; tannins; willow;

D O I：

10.1016/0031-9422(90)80054-K

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Chemical investigation of medicinal willow bark (Salix spp. has led to the isolation and characterization of four dimeric (B1, B3, B6, B7, and five trimeric procyanidins. The structures of the triflavanoids were established on the basis of spectroscopic evidence. Circular dichroism combined with the application of diagnostic chemical shifts of heterocyclic and aromatic protons available from high-temperature 1H NMR spectroscope permitted the structural elucidation of the dodecamethyl ether triacetates of catechin-(4α→8)-catechin-(4α→8)-catechin (C2), epicatechin-(4β→8)-epicatechin-(4β→8)-catechin, catechin-(4α→8)-catechin-(4α→6)-catechin, catechin-(4α→8)-epicatechin-(4β→8)-epicatechin and its (4α→6,4β→8)-isomer. The last three compounds are being reported from a natural source for the first time. © 1990.

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页码：955 / 960

页数：6

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