HIGH SERUM ADENOSINE-DEAMINASE ACTIVITY AND ITS CORRELATION WITH LYMPHOCYTE SUBSETS IN MYASTHENIA-GRAVIS

被引：9

作者：

CHIBA, S

MATSUMOTO, H

MOTOI, Y

MIYANO, N

KASHIWAGI, M

机构：

[1] Department of Rehabilitation and Neurology, Sapporo Medical College, Sapporo

来源：

JOURNAL OF THE NEUROLOGICAL SCIENCES | 1990年 / 100卷 / 1-2期

关键词：

MYASTHENIA GRAVIS; ADENOSINE DEAMINASE; LYMPHOCYTES; OK IA1+ CELLS;

D O I：

10.1016/0022-510X(90)90030-Q

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Serum adenosine deaminase (ADA) activity and peripheral lymphocyte subsets of patients with myasthenia gravis (MG) were simultaneously measured. The ADA activity in MG (n = 30) was significantly higher as compared with normal control (n = 150) and multiple sclerosis (n = 12) (P < 0.05). The ADA activity of generalized MG was higher than that of ocular MG, while a significant elevation of ADA activity was observed in grade IIB as compared with grade I of Osserman's classification (P < 0.05). A trend of high ADA activity was demonstrated in those whose disease had advanced to a severe degree associated with unstable clinical features (P < 0.05). In addition, there was a significant elevation of ADA activity in patients who disclosed positive anti-Ach-receptor-antibody as compared with negative one (P < 0.05). There was no specific trend among the proportions of the subsets of peripheral lymphocytes which could reflect the severity of MG, however, the proportion of OK Ia1 + tended to be higher with advancing the grade of MG. Interestingly enough, a close correlation was found between the ADA activity and the proportion of OK Ia1 + cells (P < 0.05). From the above results, it was concluded that high ADA may be responsible for the pathophysiology of MG through the alteration of peripheral lymphocyte function.

引用

页码：174 / 177

页数：4

共 17 条

[1]

Bertouch, Robert-Thompson, Bradley, Diurnal variation of lymphocyte subsets identified by monoclonal antibodies, Br. Med. J., 286, pp. 1171-1172, (1983)

[2]

Chechik, Schrader, Minowada, An immunomorphological study of adenosine deaminase distribution in human thymus tissue, normal lymphocytes, and hematopoietic cell line, J. Immunol., 126, pp. 1003-1007, (1981)

[3]

Chechik, Sengupta, Detection of human, rat and mouse adenosine deaminase by immunochemical and immunomorphologic methods using antiserum to calf enzyme, J. Immunol. Methods, 45, pp. 165-176, (1981)

[4]

Geiger, Nagy, Distribution of adenosine deaminase activity in rat brain and spinal cord, J. Neurosci., 6, pp. 2707-2714, (1986)

[5]

Giblett, Anderson, Cohen, Pollara, Meuwissen, Adenosine-deaminase deficiency in two patients with severely impaired cellular immunity, Lancet, 2, pp. 1067-1069, (1972)

[6]

Lennon, McCormick, Lambert, Giesmann, Atassi, Region of peptide 125–147 of acetylcholine receptor subunit is exposed at neuromuscular juction and induces experimental autoimmune myasthenia gravis, T cell immunity, and modulating autoantibodies, Proc. Natl. Acad. Sci. USA, 82, pp. 8805-8809, (1985)

[7]

Mossan, Vincent, Newsom-Davis, Ig serum factor in anti-AchR negative myasthenia gravis impairs neuro- muscular transmission, Journal of Neurology, 232, (1985)

[8]

Murray, Reuben, Munn, Newell, Mansell, Hersh, In vitro modulation of purine enzyme metabolism and lymphocyte surface marker expression by thymosin 5 in homosexual males, Int. J. Immunopharmacol, 7, pp. 661-669, (1985)

[9]

Norstrand, A molecular hypothesis concerning the pathogenesis of myasthenia gravis, Med. Hypoth., 16, pp. 365-369, (1985)

[10]

Olanow, Weshler, Sirotokin-Roses, Stajich, Roses, Thymectomy as primary therapy in myasthenia gravis, Annals of the New York Academy of Sciences, 505, pp. 595-606, (1981)

← 1 2 →