BIOCONVERSION OF ARTEANNUIN-B TO ARTEMISININ

被引：49

作者：

NAIR, MSR

BASILE, DV

机构：

[1] Department of Biological Sciences, H.H. Lehman College of CUNY, The Bronx, New York

来源：

JOURNAL OF NATURAL PRODUCTS | 1993年 / 56卷 / 09期

关键词：

D O I：

10.1021/np50099a015

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Arteannuin B, which co-occurs with artemisinin, the potent antimalarial principle of the Chinese medicinal herb Artemisia annua (Asteraceae), has been converted to the latter using crude and semi-purified cell-free extracts of the leaf homogenates of the plant. Detection procedures to quantitate this bioconversion, including one that is novel which uses gc-ms, are detailed.

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页码：1559 / 1566

页数：8

相关论文

共 39 条

[1] REDUCTIVE ELECTROCHEMICAL HPLC ASSAY FOR ARTEMISININ (QINGHAOSU) [J].

ACTON, N ;

KLAYMAN, DL ;

ROLLMAN, IJ .

PLANTA MEDICA, 1985, 51 (05) :445-446

[2]

ACTON N, 1989, J CHEM EDUC, V66, P349

[3] BIOSYNTHESIS OF ARTEMISINIC ACID IN ARTEMISIA-ANNUA [J].

AKHILA, A ;

RANI, K ;

THAKUR, RS .

PHYTOCHEMISTRY, 1990, 29 (07) :2129-2132

[4] BIOSYNTHESIS OF ARTEMISININ IN ARTEMISIA-ANNUA [J].

AKHILA, A ;

THAKUR, RS ;

POPLI, SP .

PHYTOCHEMISTRY, 1987, 26 (07) :1927-1930

[5]

[Anonymous], 1982, J TRADIT CHIN MED, V2, P9

[6] ARTEETHER, A NEW ANTIMALARIAL DRUG - SYNTHESIS AND ANTIMALARIAL PROPERTIES [J].

BROSSI, A ;

VENUGOPALAN, B ;

GERPE, LD ;

YEH, HJC ;

FLIPPENANDERSON, JL ;

BUCHS, P ;

LUO, XD ;

MILHOUS, W ;

PETERS, W .

JOURNAL OF MEDICINAL CHEMISTRY, 1988, 31 (03) :645-650

[7] ON THE POSSIBLE ROLE OF QUINGHAO ACID IN THE BIOSYNTHESIS OF ARTEMISININ [J].

ELFERALY, FS ;

ALMESHAL, IA ;

ALYAHYA, MA ;

HIFNAWY, MS .

PHYTOCHEMISTRY, 1986, 25 (12) :2777-2778

[8] ONE-STEP STEREOSPECIFIC SYNTHESIS OF (-)-ARTEANNUIN-B [J].

JUNG, M ;

YOO, Y ;

ELSOHLY, HN ;

MCCHESNEY, JD .

JOURNAL OF NATURAL PRODUCTS, 1987, 50 (05) :972-973

[9] QINGHAOSU (ARTEMISININ) - AN ANTIMALARIAL DRUG FROM CHINA [J].

KLAYMAN, DL .

SCIENCE, 1985, 228 (4703) :1049-1055

[10] EFFECT OF STEROL INHIBITORS ON THE INCORPORATION OF C-14 ISOPENTENYL PYROPHOSPHATE INTO ARTEMISININ BY A CELL-FREE SYSTEM FROM ARTEMISIA-ANNUA TISSUE-CULTURES AND PLANTS [J].

KUDAKASSERIL, GJ ;

LAM, L ;

STABA, EJ .

PLANTA MEDICA, 1987, (03) :280-284

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