THE SYNTHESIS OF CONFORMATIONALLY ROTATIONALLY RESTRICTED ANALOGS OF THE NEUROTRANSMITTER SEROTONIN

被引：20

作者：

MACOR, JE

BLANK, DH

POST, RJ

机构：

[1] Department of Medicinal Chemistry, Central Research Division, Pfizer Inc, Groton

来源：

TETRAHEDRON LETTERS | 1994年 / 35卷 / 01期

关键词：

D O I：

10.1016/0040-4039(94)88158-8

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The syntheses of two novel conformationally/rotationally restricted analogs of the neurotransmitter serotonin which are modeled after the 5-HT2 receptor selective agonist CP-132,484 [a dihydropyrano[3,2-e]indole] are described.

引用

页码：45 / 48

页数：4

共 13 条

[1]

AOYAMA T, 1981, CHEM PHARM BULL, V29, P3249

[2]

COLONNA M, 1962, GAZZ CHIM ITAL, V92, P1401

[3] SEROTONIN RECEPTORS - CLINICAL IMPLICATIONS [J].

GLENNON, RA .

NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS, 1990, 14 (01) :35-47

[4] A PROPOSED NEW NOMENCLATURE FOR 5-HT RECEPTORS [J].

HUMPHREY, PPA ;

HARTIG, P ;

HOYER, D .

TRENDS IN PHARMACOLOGICAL SCIENCES, 1993, 14 (06) :233-236

[5] SYNTHESIS AND SEROTONERGIC PHARMACOLOGY OF THE ENANTIOMERS OF 3-[(N-METHYLPYRROLIDIN-2-YL)METHYL]-5-METHOXY-1H-INDOLE - DISCOVERY OF STEREOGENIC DIFFERENTIATION IN THE AMINOETHYL SIDE-CHAIN OF THE NEUROTRANSMITTER SEROTONIN [J].

MACOR, JE ;

BLAKE, J ;

FOX, CB ;

JOHNSON, C ;

KOE, BK ;

LEBEL, LA ;

MORRONE, JM ;

RYAN, K ;

SCHMIDT, AW ;

SCHULZ, DW ;

ZORN, SH .

JOURNAL OF MEDICINAL CHEMISTRY, 1992, 35 (23) :4503-4505

[6]

MACOR JE, 1990, HETEROCYCLES, V31, P1497

[7]

MACOR JE, 1990, HETEROCYCLES, V31, P805

[8] THE SYNTHESIS OF PYRANO[3,2-E]INDOLES AND PYRANO[2,3-F]INDOLES AS ROTATIONALLY RESTRICTED PHENOLIC ANALOGS OF THE NEUROTRANSMITTER SEROTONIN [J].

MACOR, JE ;

RYAN, K ;

NEWMAN, ME .

TETRAHEDRON, 1992, 48 (06) :1039-1052

[9] 3-(1,2,5,6-TETRAHYDROPYRID-4-YL)PYRROLO[3,2-B]PYRID-5-ONE - A POTENT AND SELECTIVE SEROTONIN (5-HT1B) AGONIST AND ROTATIONALLY RESTRICTED PHENOLIC ANALOG OF 5-METHOXY-3-(1,2,5,6-TETRAHYDROPYRID-4-YL)INDOLE [J].

MACOR, JE ;

BURKHART, CA ;

HEYM, JH ;

IVES, JL ;

LEBEL, LA ;

NEWMAN, ME ;

NIELSEN, JA ;

RYAN, K ;

SCHULZ, DW ;

TORGERSEN, LK ;

KOE, BK .

JOURNAL OF MEDICINAL CHEMISTRY, 1990, 33 (08) :2087-2093

[10] 1-(2-AMINOETHYL)-3-METHYL-8,9-DIHYDROPYRANO[3,2-E]INDOLE - A ROTATIONALLY RESTRICTED PHENOLIC ANALOG OF THE NEUROTRANSMITTER SEROTONIN AND AGONIST SELECTIVE FOR SEROTONIN (5-HT2-TYPE) RECEPTORS [J].

MACOR, JE ;

FOX, CB ;

JOHNSON, C ;

KOE, BK ;

LEBEL, LA ;

ZORN, SH .

JOURNAL OF MEDICINAL CHEMISTRY, 1992, 35 (20) :3625-3632

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