CRF ADMINISTERED TO PREGNANT RATS ALTERS OFFSPRING BEHAVIOR AND MORPHOLOGY

被引：47

作者：

WILLIAMS, MT

HENNESSY, MB

DAVIS, HN

机构：

[1] Department of Psychology, Wright State University, Dayton

来源：

PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR | 1995年 / 52卷 / 01期

关键词：

CRF; STRESS; PRENATAL; ULTRASONIC VOCALIZATIONS (USV);

D O I：

10.1016/0091-3057(95)00082-8

中图分类号：

B84 [心理学]; C [社会科学总论]; Q98 [人类学];

学科分类号：

03 ; 0303 ; 030303 ; 04 ; 0402 ;

摘要：

Pregnant rats injected with 20 mu g of corticotropin-releasing factor (CRP) from day 14 through 21 gained less weight during gestation than did saline-injected controls. The offspring of CRF-injected females differed from the offspring of control females in several ways: males and females weighed less during the first 2 weeks of life, males had shorter anogenital distances at birth, and males and females emitted more ultrasonic vocalizations during isolation in tests at 6 and 14 days of age. These effects are similar to those that have been observed following exposure of pregnant females to stressors, and provide support for the notion that CRF and/or CRF activation of the hypothalamic-pituitary-adrenal axis mediate effects of gestational stress.

引用

页码：161 / 167

页数：7

共 68 条

[1] STATISTICAL PROCEDURE IN DEVELOPMENTAL STUDIES ON SPECIES WITH MULTIPLE OFFSPRING [J].