TRANSPLACENTAL EFFECTS OF NITROSAMINES IN SYRIAN-HAMSTERS .1. DIBUTYLNITROSAMINE AND NITROSOHEXAMETHYLENEIMINE

被引:14
作者
ALTHOFF, J
POUR, P
GRANDJEAN, C
EAGEN, M
机构
[1] UNIV NEBRASKA, MED CTR, EPPLEY INST RES CANC, OMAHA, NE 68105 USA
[2] MED HSCH HANNOVER, EXPTL PATHOL ABT, D-3000 HANNOVER, BUNDES REPUBLIK
来源
ZEITSCHRIFT FUR KREBSFORSCHUNG UND KLINISCHE ONKOLOGIE | 1976年 / 86卷 / 01期
关键词
D O I
10.1007/BF00304935
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
The transplacental carcinogenic effects of dibutylnitrosamine (DBN) and nitrosohexamethyleneimine (N-6-MI) were examined in Syrian hamsters. A proportion of both substances reached the fetal tissue unaltered. No macroscopic malformations were observed in the offspring. Postnatal mortality was high. Respiratory tumors were found on histologic examination of surviving animals. Single doses of 30 mg/kg body weight (b.w.) DBN and 2 doses of 10 mg/kg b.w. N-6-MI did not induce tumors in the P[parental]-generation, but led to a low tumor incidence in the F1 generation (DBN, 7.0%; N-6-MI, 2.0%). Treatment up to 8 days during the 2nd half of pregnancy led to a higher tumor incidence in the P generation (DBN, 22%; N-6-MI, 20%), than in the F1 generation (DBN, 6.0%; N-6-MI, 10%).
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页码:69 / 75
页数:7
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