Eight cases of proliferative spindle cell nodules that developed 5 wk-3 mo. after operations on the lower genital tract of 4 women, and the lower urinary tract of 4 men, are described. The lesions ranged up to 4 cm in diameter, resembled spindle cell sarcomas on microscopical examinations and were initially interpreted as such in most of the cases. Of the lesions, 6 were treated by local excision alone and 2 by a radical surgical procedure, followed by radiation therapy in 1 case. The 6 patients whose lesions were treated inadequately on the assumption that they were sarcomas were free of disease 9-60 mo. (average, 28 mo.) postoperatively, and the 2 men who were treated by radical procedures were well 18 and 60 mo. later. The microscopic features, the unusual clinical setting and the favorable prognosis of these lesions suggest that they were examples of an undescribed form of benign reactive lesion resembling a sarcoma.