CSF METABOLITES IN BORDERLINE PERSONALITY-DISORDER COMPARED WITH NORMAL CONTROLS

被引：81

作者：

GARDNER, DL ^{[1
]}

LUCAS, PB ^{[1
]}

COWDRY, RW ^{[1
]}

机构：

[1] NIMH, CLIN NEUROSCI BRANCH, BETHESDA, MD 20205 USA

来源：

BIOLOGICAL PSYCHIATRY | 1990年 / 28卷 / 03期

关键词：

D O I：

10.1016/0006-3223(90)90580-U

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Cerebrospinal metabolites were measured in 17 patients with borderline personality disorder and 17 normal controls. There were no significant differences between the two groups in levels of 5-hydroxyindoleacetic acid (5-HIAA), homovanillic acid (HVA), or 3-methoxy-4-hydroxyphenylglycol (MHPG). Within the borderline group, lower levels of CSF 5-HIAA were significantly associated with a history of genuine suicide attempts, but were not associated with violence, self-mutilation, or with the presence of major depression. Thus, CSF 5-HIAA levels are not distinctively low in a diagnostic group characterized by impulsivity and suicidal behavior, but within that group may be associated with genuine suicide attempts. © 1990.

引用

页码：247 / 254

页数：8

共 34 条

[1] SYMPTOM PATTERNS IN UNIPOLAR AND BIPOLAR DEPRESSION CORRELATING WITH MONOAMINE METABOLITES IN THE CEREBROSPINAL-FLUID .2. SUICIDE [J].