THE EFFECT OF PANCREATIC-POLYPEPTIDE AND PEPTIDE-YY ON PANCREATIC BLOOD-FLOW AND PANCREATIC EXOCRINE SECRETION IN THE ANESTHETIZED DOG

被引：18

作者：

DEMAR, AR ^{[1
]}

LAKE, R ^{[1
]}

FINK, AS ^{[1
]}

机构：

[1] UNIV CINCINNATI,MED CTR,DEPT SURG,231 BETHESDA AVE,CINCINNATI,OH 45267

来源：

PANCREAS | 1991年 / 6卷 / 01期

关键词：

Pancreatic blood flow; Pancreatic inhibition; Pancreatic polypeptide; Pancreatic secretion; Peptide YY;

D O I：

10.1097/00006676-199101000-00002

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Pancreatic polypeptide (PP) and peptide YY (PYY) are inhibitors of pancreatic exocrine secretion in vivo but not in vitro, which suggests intermediate mechanisms of action. To examine the role of pancreatic blood flow in these inhibitory effects, xenon-133 gas clearance was used to measure pancreatic blood flow while simultaneously measuring pancreatic exocrine secretion. PP or PYY (400 pmol/kg/h) was administered during the intermediate hour of a 3-h secretin (125 ng/kg/h)/cholecystokinin octapeptide (CCK-8) (50 ng/kg/h) infusion. Exocrine secretion and pancreatic blood flow during the PP or PYY hours were compared with that observed in the first and third hours of the secretin/CCK-8 infusion. PP and PYY significantly inhibited secretin/ CCK-8-induced pancreatic exocrine secretion. In addition, PYY (but not PP) significantly reduced pancreatic blood flow during secretin/CCK-8 stimulation. Nevertheless, there was no correlation between pancreatic blood flow and bicarbonate or protein outputs. It is concluded that changes in pancreatic blood flow do not mediate the inhibitory effects of PP or PYY on the exocrine pancreas. © 1991 Raven Press, New York.

引用

页码：9 / 14

页数：6

共 21 条

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