SYNTHESIS OF (-)-EGENINE (DECUMBENSINE) BY ASYMMETRIC CARBONYL ADDITION

被引：23

作者：

REIN, KS ^{[1
]}

GAWLEY, RE ^{[1
]}

机构：

[1] UNIV MIAMI,DEPT CHEM,CORAL GABLES,FL 33124

来源：

TETRAHEDRON LETTERS | 1990年 / 31卷 / 26期

关键词：

D O I：

10.1016/S0040-4039(00)97451-3

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The first synthesis of the phthalideisoquinoline hemiacetal egenine is reported, along with spectral data suggesting that egenine and decumbensine are one and the same. These synthetic studies are part of a larger investigation into the face-selectivity of additions of chiral dipole-stabilized organometallics to aldehydes. The synthesis of egenine and the correlation to bicuculline diol establish the absolute configuration of the major stereoisomer formed as being opposite to that expected based on earlier work. © 1990.

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页码：3711 / 3714

页数：4

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