NORMAL SERUM IMMUNOGLOBULINS INFLUENCE THE NUMBERS OF BONE-MARROW PRE-B AND B-CELLS

被引：52

作者：

SUNDBLAD, A ^{[1
]}

MARCOS, M ^{[1
]}

HUETZ, F ^{[1
]}

FREITAS, A ^{[1
]}

HEUSSER, C ^{[1
]}

PORTNOI, D ^{[1
]}

COUTINHO, A ^{[1
]}

机构：

[1] CIBA GEIGY AG,RES DEPT,CH-4002 BASEL,SWITZERLAND

来源：

EUROPEAN JOURNAL OF IMMUNOLOGY | 1991年 / 21卷 / 05期

关键词：

D O I：

10.1002/eji.1830210510

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The homeostatic mechanisms controlling B lymphocyte output from bone marrow are not well understood. The present experiments evaluated putative influences of circulating immunoglobulins (Ig) on bone marrow (BM) pre-B and B cell populations. Injections into normal mice of Ig isolated from normal mouse serum, resulted in a dose-dependent and reversible reduction in numbers of BM B lineage cells, in particular of small B220+ surface IgM- cells. Maximal effects were observed upon injection of isologous polyclonal Ig and were independent of mature T cells. These results suggest a feedback modulation of peripheral Ig on cellular activities in BM B lineage compartments, mediated by mechanisms that seem to involve the variable regions of the Ig molecule.

引用

页码：1155 / 1161

页数：7

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