MUCOSAL IMMUNIZATION WITH A SUBUNIT RESPIRATORY SYNCYTIAL VIRUS-VACCINE IN MICE

被引：26

作者：

WALSH, EE

机构：

[1] UNIV ROCHESTER, ROCHESTER, NY 14627 USA

[2] UNIV ROCHESTER, SCH MED & DENT, ROCHESTER, NY 14642 USA

来源：

VACCINE | 1993年 / 11卷 / 11期

关键词：

RESPIRATORY SYNCYTIAL VIRUS; MUCOSAL IMMUNIZATION; SUBUNIT VACCINE;

D O I：

10.1016/0264-410X(93)90075-9

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The protective efficacy of mucosal immunization with purified respiratory syncytial virus (RSV) fusion protein (F) using cholera toxin (CT) as an adjuvant was assessed in mice. Intranasal vaccination with F+CT induced F-specific serum IgG and nasal IgA and resulted in 75% protection from nasal virus replication compared with control mice. Intranasal CT+F with simultaneous parenteral F provided complete protection equivalent to intranasal live virus immunization.

引用

收藏

页码：1135 / 1138

页数：4

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