FUNCTIONALIZATION OF 1,2,3-TRIAZOLE VIA LITHIATION OF 1-[2-(TRIMETHYLSILYL)ETHOXY]METHYL-1H-1,2,3-TRIAZOLE

被引：16

作者：

HOLZER, W

RUSO, K

机构：

[1] Institute of Pharmaceutical Chemistry, University of Vienna, Vienna, A-1090

来源：

JOURNAL OF HETEROCYCLIC CHEMISTRY | 1992年 / 29卷 / 05期

关键词：

D O I：

10.1002/jhet.5570290526

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The preparation of a number of 5-substituted 1-[2-(trimethylsilyl)ethoxy]methyl-1H-1,2,3-triazoles via reaction of 1-[2-(trimethylsilyl)ethoxy]methyl-1H-1,2,3-triazole with n-butyllithium followed by addition of various electrophiles is reported. Removal of the protecting group by action of diluted aqueous hydrochloric acid or by tetrabutylammonium fluoride in tetrahydrofuran leads to the appropriate 4-substituted 1H-1,2,3-triazoles.

引用

页码：1203 / 1207

页数：5

共 22 条

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