THE CONCENTRATION OF N-ACETYL ASPARTATE, CREATINE PLUS PHOSPHOCREATINE, AND CHOLINE IN DIFFERENT PARTS OF THE BRAIN IN ADULTHOOD AND SENIUM

被引：155

作者：

CHRISTIANSEN, P

TOFT, P

LARSSON, HBW

STUBGAARD, M

HENRIKSEN, O

机构：

[1] Danish Research Center of Magnetic Resonance, Hvidovre Hospital, University of Copenhagen

来源：

MAGNETIC RESONANCE IMAGING | 1993年 / 11卷 / 06期

关键词：

HUMAN BRAIN; 1H-MRS; STEAM; QUANTITATION; HEALTHY VOLUNTEERS; SPECTROSCOPY;

D O I：

10.1016/0730-725X(93)90197-L

中图分类号：

R8 [特种医学]; R445 [影像诊断学];

学科分类号：

1002 ; 100207 ; 1009 ;

摘要：

The fully relaxed water signal was used as an internal standard in a STEAM experiment to calculate the concentrations of the metabolites: N-acetyl aspartate (NAA), creatine + phosphocreatine (Cr + PCr), and choline (Cho) containing compounds in four different parts of the brain in two age groups of healthy volunteers (20-30 yr, n = 8) and (60-80 yr, n = 8). Furthermore, T1 and T2 relaxation time of the metabolites and signal ratios: NAA/Cho, NAA/Cr + PCr, and Cho/Cr + PCr at TE = 272 msec were calculated. The experiments were carried out using a Siemens Helicon SP 63/84 wholebody MR-scanner at 1.5 T. In the younger age group, the concentration of NAA wag significantly higher in the occipital part than in the other three parts of the brain. No significant regional variation was found for any other metabolite concentration. There was a significantly higher concentration of NAA in the occipital part of the brain in the younger age group compared to the older one. No significant regional or age dependent variation was found concerning the T1 and T2 relaxation times.

引用

页码：799 / 806

页数：8

共 14 条

[1] Tofts, Wray, A critical assessment of methods of measuring metabolite concentrations by NMR-spectroscopy, NMR. Biomed., 1, pp. 1-10, (1988)
[2] Frahm, Bruhn, Gyngell, Merboldt, Haniche, Sauter, Localized proton NMR spectroscopy in different regions of the human brain in vivo. Relaxation times and concentration of cerebral metabolites, Magn. Reson. Med., 11, pp. 47-63, (1989)
[3] Narayana, Fotedar, Jackson, Bohan, Butler, Wolinsky, Regional in vivo proton magnetic resonance spectroscopy of brain, J. Magn. Reson., 83, pp. 44-52, (1989)
[4] Christiansen, Henriksen, Stubgaard, Gideon, Larsson, In vivo quantification of brain metabolites by <sup>1</sup>H-MRS using water as an internal standard, Magn. Reson. Imaging, 11, pp. 107-118, (1993)
[5] Hennig, Pfister, Ernst, Ott, Direct absolute quantification of metabolites in the human brain with in vivo localized proton spectroscopy, NMR. Biomed., 5, pp. 193-199, (1992)
[6] Kreis, Ernst, Ross, Quantitative proton MRS in the human brain: Biochemical and clinical benefits, Book of abstracts: Eleventh Annual Meeting of the Society of Magnetic Resonance in Medicine, (1992)
[7] Frahm, Bruhn, Gyngell, Merboldt, Hanicke, Sauter, Localized high-resolution proton NMR spectroscopy using stimulated echoes: Initial applications to human brain in vivo, Magn. Reson. Med., 9, pp. 79-93, (1989)
[8] Norton, Poduslo, Suzuki, Subacute sclerosing leukoencephalitis II. Chemical studies including abnormal myelin and abnormal ganglioside pattern, J. Neuropathol. Exp. Neurol., 25, pp. 582-597, (1966)
[9] Birken, Oldendorf, N-acetyl aspartate acid: A literature review of a compound prominent in <sup>1</sup>H-NMR spectroscopic studies of the brain, Neurosci. Biobehav. Rev., 13, pp. 23-31, (1989)
[10] Narayana, Johnston, Flamig, In vivo proton magnetic resonance spectroscopy studies of human brain, Magn. Reson. Imaging, 9, pp. 303-308, (1991)

← 1 2 →