AMYGDALA N-METHYL-D-ASPARTATE RECEPTORS PARTICIPATE IN THE INDUCTION OF LONG-TERM POTENTIATION IN THE DENTATE GYRUS IN-VIVO

被引：26

作者：

IKEGAYA, Y ^{[1
]}

SAITO, H ^{[1
]}

ABE, K ^{[1
]}

机构：

[1] UNIV TOKYO,FAC PHARMACEUT SCI,DEPT CHEM PHARMACOL,TOKYO 113,JAPAN

来源：

NEUROSCIENCE LETTERS | 1995年 / 192卷 / 03期

关键词：

LONG-TERM POTENTIATION; HIPPOCAMPUS; BASOLATERAL AMYGDALA; N-METHYL-D-ASPARTATE RECEPTOR; AMYGDALO HIPPOCAMPAL INTERACTION; SYNAPTIC PLASTICITY;

D O I：

10.1016/0304-3940(95)11643-B

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

We investigated the effects of injection of N-methyl-D-aspartate (NMDA) receptor antagonists, 2-amino-5-phosphonovalerate (APV) and 7-chlorokynurenate (7-Cl-Kyn), into the basolateral amygdala (BLA) on long-term potentiation (LTP) in the medial perforant path-dentate gyrus granule cell synapses of anesthetized rats. Injection of APV or 7-Cl-Kyn into the ipsilateral BLA did not affect the baseline synaptic responses, but significantly attenuated the dentate gyrus LTP induced by tetanic stimulation. Injection of APV into the contralateral BLA did not affect the induction of LTP. When APV was injected after tetanic stimulation, it did not affect the maintenance phase of LTP. These results suggest that NMDA receptors in the ipsilateral BLA partly participate in the induction of LTP in the dentate gyrus in vivo.

引用

页码：193 / 196

页数：4

共 25 条

[1]

Aggleton, A description of the amygdalo-hippocampal interconnections in the masque monkey, Exp. Brain Res., 64, pp. 515-526, (1986)

[2]

Bliss, Collingridge, A synaptic model of memory: long-term potentiation in the hippocampus, Nature, 361, pp. 31-39, (1993)

[3]

Cahill, McGaugh, The functional anatomy of amygdala efferent pathways, Soc. Neurosci. Abstr., 19, (1993)

[4]

Chapman, Kairiss, Keenan, Brown, Long-term synaptic potentiation in the amygdala, Synapse, 6, pp. 271-278, (1990)

[5]

Collingridge, Bliss, NMDA receptors-their role in long-term potentiation, Trends. Neurosci., 10, pp. 288-293, (1987)

[6]

Fanselow, Kim, Acquisition of contextual Pavlovian fear conditioning is blocked by application of an NMDA receptor antagonist d,l-2-amino-5-phosphonovaletic acid to the basolateral amygdala, Behav. Neurosci., 108, pp. 210-212, (1994)

[7]

Gaffan, Harrison, Visual-visual associative memory and reward association learning and monkeys: the role of the amygdala, J. Neurosci., 9, pp. 558-564, (1989)

[8]

Gallagher, Kapp, Musty, Driscoll, Memory formation: evidence for a specific neurochemical system in the amygdala, Science, 198, pp. 423-425, (1977)

[9]

Gean, Chan, Huang, Lin, Way, Long-term enhancement of EPSP and NMSA receptor-mediated synaptic transmission in the amygdala, Brain Res. Bull., 31, pp. 7-11, (1993)

[10]

Ikegaya, Saito, Abe, Attenuated hippocampal long-term potentiation in basolateral amygdala-lesioned rats, Brain Res., 656, pp. 157-164, (1994)

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