ANTIHISTONE ANTIBODIES IN SYSTEMIC-SCLEROSIS - ASSOCIATION WITH PULMONARY FIBROSIS

被引：118

作者：

SATO, S ^{[1
]}

IHN, H ^{[1
]}

KIKUCHI, K ^{[1
]}

TAKEHARA, K ^{[1
]}

机构：

[1] UNIV TOKYO,FAC MED,DEPT DERMATOL,BUNKYO KU,TOKYO 113,JAPAN

来源：

ARTHRITIS AND RHEUMATISM | 1994年 / 37卷 / 03期

关键词：

D O I：

10.1002/art.1780370313

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Objective. To determine the prevalence and clinical significance of antihistone antibodies (AHA) in systemic sclerosis (SSc). Methods. Serum samples from patients with limited cutaneous SSc (n = 44), diffuse cutaneous SSc (dcSSc; n = 48), and other SSc-related disorders (n = 22) were examined by enzyme-linked immunosorbent assay and immunoblotting for AHA. Results. AHA were demonstrated in 29% of the 92 SSc patients and in 44% of those with dcSSc. The presence of AHA correlated with severe pulmonary fibrosis in those with dcSSc. Immunoblotting revealed that the predominant antigen was histone H1. Conclusion. AHA might be a serologic indicator of the severity of pulmonary fibrosis in SSc.

引用

页码：391 / 394

页数：4

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