DICTYOSTELIUM-DISCOIDEUM, A LOWER EUKARYOTE MODEL FOR THE STUDY OF DNA-REPAIR - IMPLICATIONS FOR THE ROLE OF DNA-DAMAGING CHEMICALS IN THE EVOLUTION OF REPAIR PROFICIENT CELLS

The evolution of the ability of living cells to cope with stress is crucial for the maintenance of their genetic integrity. Yet low levels of mutation must remain to allow adaptation to environmental changes. The cellular slime mold D. discoideum is a good system for studying molecular aspects of the repair of lethal and mutagenic damage to DNA by radiation and chemicals. The wild-type strains of this soil microorganism are extremely resistant to DNA damaging agents. In nature the amoeboid cells in their replicative stage feed on soil bacteria and are exposed to numerous DNA-damaging chemicals produced by various soil microorganisms. It is probable that the evolution of repair systems in this organism and perhaps in others is a consequence of necessity to cope wit chemical damage which also confers resistance to radiation.