HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHIC METHOD FOR ASSAY OF OTILONIUM BROMIDE, DIAZEPAM, AND RELATED-COMPOUNDS IN FINISHED PHARMACEUTICAL FORMS

被引：16

作者：

MANNUCCI, C ^{[1
]}

BERTINI, J ^{[1
]}

COCCHINI, A ^{[1
]}

PERICO, A ^{[1
]}

SALVAGNINI, F ^{[1
]}

TRIOLO, A ^{[1
]}

机构：

[1] A MENARINI IND FARMACEUT RIUNITE SRL,ANALYT RES DEPT,VIA SETTE SANTI 3,I-50131 FLORENCE,ITALY

来源：

JOURNAL OF PHARMACEUTICAL SCIENCES | 1993年 / 82卷 / 04期

关键词：

D O I：

10.1002/jps.2600820406

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A rapid, simple, stability-indicating assay procedure for otilonium bromide, a smooth muscle relaxant agent, and diazepam in composite tablet analysis was developed with high-performance liquid chromatography. The tablet matrix was dissolved with water, and drugs were extracted with acetonitrile containing an internal standard. An aliquot was centrifuged and chromatographed on a 5-mum, reversed-phase column with 0.5 M sodium acetate trihydrate buffer containing 5 mM 1-heptanesulfonic acid monohydrate sodium salt:methanol (30:70; v/v; adjusted to pH 6.0 with glacial acetic acid) as the mobile phase. The selectivity of the chromatographic system was demonstrated by resolving both compounds from various potential degradation products of each compound. The method is linear, quantitative, and reproducible.

引用

页码：367 / 370

页数：4

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