EFFECTS OF PANCREATICOBILIARY DIVERSION AND GASTRIC FUNDECTOMY ON AZASERINE-INDUCED PANCREATIC CARCINOGENESIS IN THE RAT

被引:13
作者
CHU, M
FRANZEN, L
SULLIVAN, S
REHFELD, JF
IHSE, I
BORCH, K
机构
[1] LINKOPING UNIV HOSP,DEPT SURG,S-58185 LINKOPING,SWEDEN
[2] UNIV COPENHAGEN,RIGSHOSP,DEPT CLIN CHEM,DK-2100 COPENHAGEN,DENMARK
[3] LINKOPING UNIV HOSP,DEPT PATHOL,S-58185 LINKOPING,SWEDEN
[4] LINKOPING UNIV HOSP,DEPT ONCOL,S-58185 LINKOPING,SWEDEN
关键词
ATYPICAL ACINAR CELL FOCI; AZASERINE; CHOLECYSTOKININ; FUNDECTOMY; GASTRIN; NODULES; PANCREAS; PANCREATICOBILIARY DIVERSION;
D O I
10.1097/00006676-199305000-00008
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
The effects of pancreaticobiliary diversion (PBD) and gastric fundectomy on the pancreas in azaserine-treated rats were studied over 14 months. Sham-operated azaserine-treated animals served as controls. A significant increase in pancreatic weight and total DNA and protein content was found in PBD-operated and fundectomized animals. DNA flow cytometry showed a significantly increased ratio of tetraploid to diploid cells in pancreatic tissue in both experimental groups. Mean values of all these variables were significantly higher after PBD than after fundectomy. Acidophilic atypical acinar cell foci of the pancreas were observed in all of the experimental and 75% of the control animals. The volume density of these foci was significantly higher in each experimental group than in the controls. The volume density, radioactive thymidine labeling index, and mitotic index of the foci were significantly higher after PBD than after fundectomy. Changes consistent with pancreatic adenoma were diagnosed in the PBD group only. It is concluded that not only PBD with endogenous hypercholecystokininemia, but also fundectomy with endogenous hypergastrinemia lasting about half of the life span in rats, induces pancreatic hypertrophy and enhances the development of precancerous pancreatic changes after azaserine treatment. In comparison with PBD, fundectomy caused less pronounced changes and no observable neoplasia.
引用
收藏
页码:330 / 337
页数:8
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