USE OF TYROSINASE FOR ENZYMATIC ELIMINATION OF ACETAMINOPHEN INTERFERENCE IN AMPEROMETRIC SENSING

An effective enzymatic strategy for eliminating the common acetaminophen interference in amperometric sensing is described. The method relies on the in situ biocatalytic removal of acetaminophen by the surface-bound tyrosinase. Mushroom-containing carbon paste electrodes (rich with tyrosinase) are particularly useful for eliminating contributions from acetaminophen. Various factors affecting the efficiency of the tyrosinase-based elimination capability are explored. Selective biosensing of glucose is accomplished by the coimmobilization of glucose oxidase.