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IMPAIRED CARDIAC WORK AND OXYGEN-UPTAKE AFTER REPERFUSION OF REGIONALLY ISCHEMIC MYOCARDIUM

被引：98
作者：
KANNENGIESSER, GJ
OPIE, LH
VANDERWERFF, TJ
机构：
[1] CTR RECH ROUSSEL UCLAF, F-93230 ROMAINVILLE, FRANCE
[2] S AFRICAN MRC, DEPT MED, ISCHAEM HEART DIS RES UNIT, JOHANNESBURG, SOUTH AFRICA
[3] GROOTE SCHUUR HOSP, DEPT BIOMED ENGN, CAPE TOWN, SOUTH AFRICA
[4] UNIV CAPE TOWN, CAPE TOWN 7900, SOUTH AFRICA
来源：
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY | 1979年 / 11卷 / 02期
关键词：
Coronary artery ligation; Efficiency of heart; High energy phosphates; Isolated perfused working rat heart; Oxygen uptake; Reperfusion; Work of heart;
D O I：
10.1016/0022-2828(79)90464-4
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Transient regional left ventricular ischaemia was produced in the isolated working perfused rat heart by ligation of the left main coronary artery and subsequent release of ligature after 15 min of acute regional myocardial ischaemia. Reperfusion restored coronary flow and the oxygen uptake to preligation values but cardiac output and peak left ventricular pressures remained impaired and tissue contents of ATP did not recover. Reperfusion also failed to restore the efficiency of the heart to pre-ligation values. © 1979.
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页码：197 / 207
页数：11
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