INCREASED SERUM CONCENTRATIONS OF TYPE-I PROCOLLAGEN C-TERMINAL PROPEPTIDE AND OSTEOCALCIN DURING A SHORT COURSE OF CALCITRIOL ADMINISTRATION TO ADULT MALE-VOLUNTEERS

To investigate bone collagen metabolism during vitamin D treatment, 15 healthy males (aged 28-45) years, median 34) were treated orally with calcitriol, 2-mu-g daily for 7 days and followed for a total of 2 weeks. The serum concentration of calcitriol rose markedly (median difference and 95% confidence limits: 49% (5-82), p < 0.005) during treatment, whereas serum levels of calcidiol, and calcium remained unchanged. The serum level of procollagen type I C-terminal propeptide rose 15% (7-33, p < 0.003), whereas no alterations were observed concerning serum procollagen type III N-terminal propeptide, and serum hyaluronan. The serum concentration of osteocalcin rose concomitantly (26% (12-45), p < 0.003). All values returned to baseline levels within seven days after the treatment week. The serum levels of osteocalcin and procollagen type I C-terminal propeptide were positively correlated (r(s) = 0.71, p < 0.004) during the study. Serum procollagen type I C-terminal propeptide and serum osteocalcin did not correlate with serum procollagen type III N-terminal propeptide or serum hyaluronan either at baseline or after treatment. It is concluded that a short course of calcitriol administration to healthy males stimulates the biosynthesis of bone-related matrix proteins. By contrast, connective tissue components of predominantly extraosseous origin are not affected.