A RANDOMIZED DOUBLE-BLIND CROSSOVER TRIAL OF INTRAVENOUS LIDOCAINE IN THE TREATMENT OF NEUROPATHIC CANCER PAIN

被引：56

作者：

BRUERA, E

RIPAMONTI, C

BRENNEIS, C

MACMILLAN, K

HANSON, J

机构：

[1] Edmonton General Hospital, Edmonton

[2] Palliative Care Division, National Cancer Institute, Milan

[3] Department of Medicine and Epidemiology, Cross Cancer Institute, Edmonton

来源：

JOURNAL OF PAIN AND SYMPTOM MANAGEMENT | 1992年 / 7卷 / 03期

关键词：

LIDOCAINE; NEUROPATHIC; PAIN; CANCER;

D O I：

10.1016/S0885-3924(06)80004-7

中图分类号：

R19 [保健组织与事业（卫生事业管理）];

学科分类号：

摘要：

In a randomized, double-blind, crossover study, we evaluated the effect of intravenous lidocaine (5 mg/kg body weight over 30 min) on the neuropathic pain of advanced cancerpatients. Pain intensity, assessed by a visual analogue scale, did not show any significant difference between lidocaine and placebo infusion. The blinded choice of patients and investigators also suggested no signficant improvement from lidocaine when given by this regimen. Intravenous lidocaine does not appear to have a significant analgesic effect on neuropathic cancer pain.

引用

页码：138 / 140

页数：3

共 11 条

[1]

Foley K, The treatment of cancer pain, N Engl J Med, 313, pp. 84-95, (1985)

[2]

Bruera E, Macmillan K, Hanson J, MacDonald N, The Edmonton staging system for cancer pain: preliminary report, Pain, 37, pp. 203-209, (1989)

[3]

Kastrup J, Petersen P, Dejgard A, Angelo HR, Hilsted J, Intravenous lidocaine infusion—a new treatment of chronic painful neuropathy?, Pain, 28, pp. 69-75, (1987)

[4]

Bach FW, Jensen TS, Kastrup J, Stigsby B, Dejgard A, The effect of intravenous lidocaine on nociceptive processing in diabetic neuropathy, Pain, 40, pp. 29-34, (1990)

[5]

Petersen P, Kastrup J, Dercum's Disease (adiposis dolorosa). Treatment of the severe pain with intravenous lidocaine, Pain, 28, pp. 77-80, (1987)

[6]

Rowlingson JC, DiFazio CA, Foster J, Carron H, Lidocaine as an analgesic for experimental pain, Anesthesiology, 52, pp. 20-22, (1980)

[7]

Ellemann K, Sjogren P, Banning AM, Jensen TS, Smith T, Geertsen P, Trial of intravenous lidocaine on painful neuropathy in cancer patients, Clin J Pain, 5, pp. 291-294, (1989)

[8]

Statistical Package for the Social Sciences, (1986)

[9]

Kastrup J, Bach FW, Petersen P, Et al., Lidocaine treatment of painful diabetic neuropathy and endogenous opioid peptides in plasma, Clin J Pain, 5, pp. 239-244, (1989)

[10]

Woolf CJ, Wiesenfeld-Hallin Z, The systemic administration of local anesthetics produces a selective depression of C-afferent fiber evoked activity in the spinal cord, Pain, 23, pp. 361-374, (1985)

← 1 2 →