INHIBITING EFFECTS OF SEROTONIN AND SEROTONIN ANTAGONISTS ON THE MIGRATION OF MONONUCLEAR LEUKOCYTES

被引：20

作者：

BONDESSON, L ^{[1
]}

NORDLIND, K ^{[1
]}

LIDEN, S ^{[1
]}

SUNDSTROM, E ^{[1
]}

机构：

[1] HUDDINGE HOSP,DEPT GERIATR MED,S-14186 HUDDINGE,SWEDEN

来源：

IMMUNOPHARMACOLOGY AND IMMUNOTOXICOLOGY | 1993年 / 15卷 / 2-3期

关键词：

D O I：

10.3109/08923979309025997

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The effect of serotonin and the serotonin antagonists ketanserin, methiotepine and ICS-205-930 on the migration of leucocytes was studied by using the sealed capillary migration technique. The migration of mononuclear leucocytes was inhibited by serotonin at 10(-4) and 10(-6)-10(-10) mol/l. An inhibition of the mononuclear leucocyte migration was also caused by ICS-205-930 at 10(-4) mol/l, ketanserin at 10(-4) and 10(-8)-10(-10) mol/l and methiotepine at 10(-4) and 10(-6)-10(-8) mol/l. No inhibiting effects of serotonin br the serotonin antagonists were found on the migration of polymorphonuclear leucocytes. Thus, both serotonin and serotonin antagonists may inhibit mononuclear leucocyte migration.

引用

页码：243 / 250

页数：8

共 17 条

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