GLISOPRENINS, NEW INHIBITORS OF ACYL-COA - CHOLESTEROL ACYLTRANSFERASE PRODUCED BY GLIOCLADIUM-SP FO-1513 .2. STRUCTURE ELUCIDATION OF GLISOPRENIN-A AND GLISOPRENIN-B

被引：20

作者：

NISHIDA, H ^{[1
]}

HUANG, XH ^{[1
]}

TOMODA, H ^{[1
]}

OMURA, S ^{[1
]}

机构：

[1] KITASATO INST, BIOL FUNCT RES CTR, MINATO KU, TOKYO 108, JAPAN

来源：

JOURNAL OF ANTIBIOTICS | 1992年 / 45卷 / 10期

关键词：

D O I：

10.7164/antibiotics.45.1669

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

The structure of glisoprenins A and B, novel acyl-CoA: cholesterol acyltransferase (ACAT) inhibitors, was determined by spectroscopic analyses, mainly H-1 and C-13 NMR and MS. Glisoprenin A was deduced to be a tetrahydroxynonaprenol and glisoprenin B to be an oxidative modification of glisoprenin A.

引用

页码：1669 / 1676

页数：8