DIMETHYL(METHYLTHIO)SULFONIUM TETRAFLUOROBORATE - A REAGENT FOR DISULFIDE BOND FORMATION IN PEPTIDES

被引：14

作者：

BISHOP, P ^{[1
]}

JONES, C ^{[1
]}

CHMIELEWSKI, J ^{[1
]}

机构：

[1] PURDUE UNIV,DEPT CHEM,W LAFAYETTE,IN 47907

来源：

TETRAHEDRON LETTERS | 1993年 / 34卷 / 28期

关键词：

D O I：

10.1016/0040-4039(93)88061-M

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Dimethyl(methylthio)sulfonium tetrafluoroborate (1) has been used to deprotect a series of cysteine derivatives (BocCys-Acm, MeOBzl, Trt) with concurrent disulfide bond formation. This reagent has also been applied to the deprotection and disulfide bond formation in two peptides: a sarafotoxin A fragment and an analog of calcitonin where each peptide contains two S-protected cysteine derivatives: [Cys(Acm)]

引用

页码：4469 / 4472

页数：4

共 17 条

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