ANTICONVULSANT EFFECT OF INTRAVENTRICULAR ANTIEPILEPTIC DRUGS - EXPERIMENTAL-STUDY

被引：12

作者：

GONZALEZDARDER, JM ^{[1
]}

GARCIATENO, M ^{[1
]}

机构：

[1] UNIV CADIZ,FAC MED,DEPT NEUROSURG,CADIZ,SPAIN

来源：

NEUROLOGICAL RESEARCH | 1995年 / 17卷 / 03期

关键词：

EPILEPSY; INTRAVENTRICULAR THERAPY; PHENOBARBITAL SODIUM; PHENYTOIN; VALPROATE; MIDAZOLAM;

D O I：

10.1080/01616412.1995.11740311

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

The effect of intraventricular administration oi antiepileptic drugs on an experimental model of epileptic seizures in rats has been investigated. Animals were tested in the electroshock test measuring the time duration of the tonic phase of the convulsion. Drugs tested were sodium phenobarbital (200-500-1000 mu g), phenytoin (50-100-200-500 mu g), midazolam (100-200-500 mu g) and sodium valproate (500-1000-2000 mu g), delivered via a catheter stereotactically placed into the lateral ventricle. Control animals were tested with saline. All antiepileptic drugs showed different degrees of reduction in the duration of the tonic phase before reaching doses that produced neurological symptoms. Our results demonstrate the feasibility to control experimental seizures by means of intraventricular injection of antiepileptic drugs.

引用

页码：190 / 192

页数：3