INFRARED AND THIN-LAYER CHROMATOGRAPHY DETERMINATION OF BENZOYL PEROXIDE DEGRADATION PRODUCTS IN PHARMACEUTICALS

被引：12

作者：

GRUBER, M

KLEIN, R

FOXX, M

机构：

[1] Analytical Research Department, Dermik Laboratories, Inc., Syosset, New York

来源：

JOURNAL OF PHARMACEUTICAL SCIENCES | 1969年 / 58卷 / 05期

关键词：

Benzoyl peroxide—degradation products; Degradation; benzoyl peroxide—pharmaceuticals; IR spectrophotometry—identity; TLC—identity; analysis;

D O I：

10.1002/jps.2600580509

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Infrared qualitative analyses followed by semiquantitative thin‐layer chromatography (TLC) were utilized to determine specific degradation products formed at room temperature in pharmaceuticals containing benzoyl peroxide. Studies on pH together with USP benzoate identification tests were employed as qualitative aids. Significant amounts of benzoic acid and/or related acids were encountered as contaminants of all premixed commercially available pharmaceuticals containing benzoyl peroxide, when stored for extended periods at room temperature. Copyright © 1969 Wiley‐Liss, Inc., A Wiley Company

引用

页码：566 / &

共 8 条

[1]

[Anonymous], 1968, MERCK INDEX

[2] NEW PRODUCTS FROM THE REACTION OF BENZOYL PEROXIDE WITH BENZENE [J].