TRICYCLIC ANTI-DEPRESSANT RADIORECEPTOR ASSAY

被引：25

作者：

INNIS, RB

TUNE, L

ROCK, R

DEPAULO, R

UPRICHARD, DC

SNYDER, SH

机构：

[1] JOHNS HOPKINS UNIV,SCH MED,DEPT PHARMACOL & EXPTL THERAPEUT,BALTIMORE,MD 21205

[2] JOHNS HOPKINS UNIV,SCH MED,DEPT PSYCHIAT & BEHAV SCI,BALTIMORE,MD 21205

[3] JOHNS HOPKINS UNIV,SCH MED,DEPT LAB MED,BALTIMORE,MD 21205

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 1979年 / 58卷 / 04期

关键词：

Anticholinergic; QNB displacement; Radioreceptor assay; Tricyclic antidepressant;

D O I：

10.1016/0014-2999(79)90319-4

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

A radioreceptor assay for tricyclic antideressants described here is based on the ability of these drugs to compete with [3H]-3-quinuclidinyl benzatile (3H-QNB) for binding to muscarinic cholinergic receptors in rat brain membranes. The assay is sensitive, in that it can detect, for example, 2 ng/ml nortriptyline in plasma. Seven plasma samples from depressed patients treated with notriptyline were assayed with the radioreceptor and gas liquid chromatographic methods, and the results for these two methods were almost identical. This assay should be used continously, if at all, in patients treated with other drugs that have potent anticholinergic effects. © 1979.

引用

页码：473 / 477

页数：5

共 10 条

[1]

BRUNSWICK DJ, 1978, LIFE SCI, V22, P137, DOI 10.1016/0024-3205(78)90530-1

[2]

CREESE I, 1977, NATURE, V270, P182

[3]

GLASSMAN AH, 1978, PSYCHOPHARMACOLOGY G, P917

[4] SIMPLE, SENSITIVE AND SPECIFIC RADIORECEPTOR ASSAY FOR BETA-ADRENERGIC ANTAGONIST DRUGS [J].