THE ROLE OF LIPOPROTEINS IN THE DISTRIBUTION OF TIN ETIOPURPURIN (SNET2) IN THE TUMOR-BEARING RAT

被引：12

作者：

KESSEL, D

GARBO, GM

HAMPTON, J

机构：

[1] MED COLL OHIO,DEPT PATHOL,TOLEDO,OH 43699

[2] MED COLL OHIO,DEPT UROL,TOLEDO,OH 43699

[3] WAYNE STATE UNIV,SCH MED,DEPT MED,DETROIT,MI 48201

[4] UNIV TOLEDO,DEPT CHEM,TOLEDO,OH 43606

[5] UNIV TOLEDO,DEPT PATHOL,TOLEDO,OH 43606

来源：

PHOTOCHEMISTRY AND PHOTOBIOLOGY | 1993年 / 57卷 / 02期

关键词：

D O I：

10.1111/j.1751-1097.1993.tb02290.x

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The role of plasma lipoproteins in the distribution of the photosensitizing agent tin etiopurpurin (SnET2) was examined in male rats bearing the N-[4-(5-nitro-2-furyl)-2-thiazolyl]formamide-induced tumor. Treatment with 17alpha-ethinyl estradiol resulted in the depletion of total plasma cholesterol by >70% and a corresponding decrease in plasma lipoproteins. To both control and estradiol-treated animals, a therapeutic dose (1.5 mg/kg) of SnET2 was administered and biodistribution measured 24 h later. Estradiol treatment was not associated with differences in the distribution of SnET2 to liver, skin or tumor, or in the pattern of affinity of SnET2 to plasma albumin and lipoprotein. These results indicate that a substantial decrease in circulating lipoprotein levels does not alter patterns of SnET2 biodistribution.

引用

页码：298 / 301

页数：4

共 30 条

[1] ROLE OF HIGH-DENSITY, LOW-DENSITY AND VERY LOW-DENSITY LIPOPROTEINS IN THE TRANSPORT AND TUMOR-DELIVERY OF HEMATOPORPHYRIN INVIVO [J].