LEAD AS AN INDUCTOR OF SOME MORPHOLOGICAL AND FUNCTIONAL-CHANGES IN SYNAPTOSOMES FROM RAT-BRAIN

被引：19

作者：

JABLONSKA, L ^{[1
]}

WALSKI, M ^{[1
]}

RAFALOWSKA, U ^{[1
]}

机构：

[1] POLISH ACAD SCI,MED RES CTR,DEPT NEUROCHEM,PL-00784 WARSAW,POLAND

来源：

CELLULAR AND MOLECULAR NEUROBIOLOGY | 1994年 / 14卷 / 06期

关键词：

LEAD; BRAIN SYNAPTOSOMES; NEUROTRANSMITTER UPTAKE;

D O I：

10.1007/BF02088678

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

1. The effect of lead (in vivo) on the uptake of GABA, dopamine, and histidine as a precursor of histamine in synaptosomes obtained from chronically lead-treated rats was studied. 2. Lead decreased the uptake of GABA, increased the uptake of dopamine, and did not change the uptake of histidine. These effects were independent of calcium concentration. 3. Lead administration to the rat changed the morphology of the synaptosomes, as manifested in the decreased number of synaptic vesicles and disturbed mitochondrial structure. 4. The results suggest the existence of several mechanisms of lead toxicity on uptake, related to individual neurotransmitters, which are not necessarily connected with a Pb2+/Ca2+ interaction.

引用

页码：701 / 709

页数：9

共 31 条

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