CONSTITUENTS OF HOUTTUYNIAE-CORDATA AND THE CRYSTAL-STRUCTURE OF VOMIFOLIOL

In the isolation of the constituents of Houttuyniae cordata, ten pure compounds including 1,3,5-tridecanoylbenzene (1), caryophyllene oxide (2), several sterones (3-6) and sesamin (7), plus long-chain alcohol mixture, a steroidal mixture and 4-hydroxybenzoic acid methyl ester (8), vomifoliol (9) [or Blumenol A], quercetin-3-O-beta-L-rhamnoside (10), were isolated from the aerial parts of H. cordata. Their structures were determined by spectral analysis. Among them, compound 1 is for the first time isolated from nature. We describe here the spectral analysis of 1, and the X-ray determination of the relative stereochemistry of vomifoliol (9).