AN EVALUATION OF SIGNAL AMPLIFICATION BY THE ION CHANNEL SENSOR BASED ON A GLUTAMATE RECEPTOR ION CHANNEL PROTEIN

被引：14

作者：

Minami, Hirotsugu ^{[1
]}

Uto, Masayuki ^{[2
]}

Sugawara, Masao ^{[1
]}

Odashima, Kazunori ^{[1
]}

Umezawa, Yoshio ^{[1
]}

Michaelis, Elias K. ^{[3
,4
]}

Kuwana, Theodore ^{[5
]}

机构：

[1] Hokkaido Univ, Fac Sci, Dept Chem, Sapporo, Hokkaido 060, Japan

[2] Kitami Inst Technol, Dept Environm Technol, Kitami, Hokkaido 090, Japan

[3] Univ Kansas, Dept Pharmacol & Toxicol, Lawrence, KS 66045 USA

[4] Univ Kansas, Ctr Biomed Res, Lawrence, KS 66045 USA

[5] Univ Kansas, Ctr Bioanalyt Res, Lawrence, KS 66046 USA

来源：

ANALYTICAL SCIENCES | 1991年 / 7卷

关键词：

coulometric biosensor; ion channel sensor; glutamate receptor ion channel; signal amplificaiton;

D O I：

10.2116/analsci.7.Supple_1675

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

An attempt was made for the evaluation of signal amplification by the ion channel sensor based on a glutamate receptor ion channel protein as a sensory element. The molecular response ratio, defined as the capability of each sensory molecule to induce a change in the number of ions permeated through the membrane, was calculated to be 1.9 x 10(7) (per second) for the single-channel sensor. The extremely high sensitivity as compared with that of the artificial systems was discussed in terms of the signal amplification indicated by the molecular response ratio.

引用

页码：1675 / 1676

页数：2

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