MICELLAR SOLUBILIZATION OF TESTOSTERONE .3. DISSOLUTION BEHAVIOR OF TESTOSTERONE IN AQUEOUS SOLUTIONS OF SELECTED SURFACTANTS

The solution behavior of testosterone was studied with a view toward explaining an anomalous initial supersaturation observed in solubilized systems containing testosterone. This anomalous behavior was related to the conversion of an anhydrous crystal form of testosterone to a hydrate crystal form. The solution behavior of the anhydrous form was studied in several concentrations of polysorbate 20, dodecyltrimethylammonium bromide, and potassium laurate. In low concentrations of polysorbate 20 and potassium laurate, the time required to attain the solubility peak was less than that in distilled water. An increase in surfactant concentration resulted in a decrease in the solubility peak time. At higher concentrations, dodecyltrimethylammonium bromide exhibited a pattern similar to that of polysorbate 20 and potassium laurate; at a low concentration, however, a prolongation of the peak solubility time was noted. Copyright © 1969 Wiley‐Liss, Inc., A Wiley Company