RADIOIMMUNOASSAY FOR 3,5-DIIODOTHYRONINE

被引：23

作者：

MEINHOLD, H ^{[1
]}

SCHURNBRAND, P ^{[1
]}

机构：

[1] FREE UNIV BERLIN,KLINIKUM STEGLITZ,DEPT ENDOCRINE,D-1000 BERLIN 45,FED REP GER

来源：

CLINICAL ENDOCRINOLOGY | 1978年 / 8卷 / 06期

关键词：

D O I：

10.1111/j.1365-2265.1978.tb02187.x

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

A radioimmunoassay for the measurement of 3,5‐diiodothyronine (3,5‐T2) using a 3H‐labelled derivative of 3,5‐T2 as tracer has been developed. The cross‐reactivity of the antiserum was relatively high for T3 (3.1%) and low for T4 (< 0.0015%). 3,5‐T2 serum concentrations measured after fractional enrichment of 3,5‐T2 were near or below the detection limit of 0.1 nmol/l in ten normal subjects and 0.38 nmol/l in five hyperthyroid patients. 3,5‐T2 was also detected in thyroid tissue. The serum half‐time of 3,5‐T2 estimated after injection of 2 mg 3,5‐T2 in three normal volunteers was 4.5 h. Copyright © 1978, Wiley Blackwell. All rights reserved

引用

页码：493 / 497

页数：5

共 7 条

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