A COMPARISON OF TOCOPHEROL AND TOCOTRIENOL FOR THE CHEMOPREVENTION OF CHEMICALLY-INDUCED RAT MAMMARY-TUMORS

被引：75

作者：

GOULD, MN

HAAG, JD

KENNAN, WS

TANNER, MA

ELSON, CE

机构：

[1] UNIV WISCONSIN, DEPT BIOSTAT, MADISON, WI 53792 USA

[2] UNIV WISCONSIN, DEPT NUTR SCI, MADISON, WI 53792 USA

来源：

AMERICAN JOURNAL OF CLINICAL NUTRITION | 1991年 / 53卷 / 04期

关键词：

TOCOTRIENOL; TOCOPHEROL; VITAMIN-E; CHEMOPREVENTION; MAMMARY CARCINOGENESIS; CANCER;

D O I：

10.1093/ajcn/53.4.1068S

中图分类号：

R15 [营养卫生、食品卫生]; TS201 [基础科学];

学科分类号：

100403 ;

摘要：

Two forms of vitamin E, tocopherol and tocotrienol, were tested for chemopreventive activity in two chemically induced rat mammary-tumor models. When mammary tumors were induced by 7,12-dimethylbenz(a)anthracene (DMBA, 50 mg/kg), only the tocotrienol group had a statistically significant increase in tumor latency. There was no effect of either compound on tumor multiplicity. When tumors were induced by N-nitrosomethylurea (NMU, 30 mg/kg), neither analogue of vitamin E modified latency, whereas tocotrienol increased tumor multiplicity. In summary, neither vitamin analog had a major impact on mammary-tumor development after tumor induction with either DMBA or NMU.

引用

页码：S1068 / S1070

页数：3