NEUROPEPTIDE SUBSTANCE-P IMPROVES WATER MAZE PERFORMANCE IN AGED RATS

被引：35

作者：

HASENOHRL, RU

HUSTON, JP

SCHUURMAN, T

机构：

[1] UNIV DUSSELDORF,INST PHYSIOL PSYCHOL,UNIV STR 1,W-4000 DUSSELDORF 1,GERMANY

[2] TROPONWERKE GMBH & CO KG,DEPT NEUROBIOL,W-5000 COLOGNE,GERMANY

来源：

PSYCHOPHARMACOLOGY | 1990年 / 101卷 / 01期

关键词：

Aging; Old rat; Spatial learning; Substance P; Water maze;

D O I：

10.1007/BF02253712

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The effects of the peripherally administered neuropeptide substance P (SP) on spatial learning capacities were investigated in 27-month-old rats using a water-maze task. Old rats were injected intraperitoneally once daily for 6 days with 50 or 250 μg/kg SP or vehicle 30 min prior to acquisition trials. Improvement in maze performance was observed following injections of 250 μg/kg SP only. Furthermore, vehicle-treated old rats showed significantly poorer acquisition rates than vehicle-treated 12-week-old rats. Thus, the improvement in performance after the 250 μg/kg dose of SP can be interpreted in terms of a compensation of performance deficit in the old rats. © 1990 Springer-Verlag.

引用

页码：23 / 26

页数：4

共 29 条

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