EFFECT OF PHENYL AND PHENOLIC-ACIDS ON MEVALONATE-5-PHOSPHATE KINASE AND MEVALONATE-5-PYROPHOSPHATE DECARBOXYLASE OF THE RAT-BRAIN

被引：11

作者：

BHAT, CS

RAMASARMA, T

机构：

[1] Department of Biochemistry, Indian Institute of Science, Bangalore

来源：

JOURNAL OF NEUROCHEMISTRY | 1979年 / 32卷 / 05期

关键词：

D O I：

10.1111/j.1471-4159.1979.tb11095.x

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Abstract— Phenyl and phenolic acids are known to inhibit metabolism of mevalonate in rat brain. The site of inhibition has been found to be mevalonate‐5‐pyrophosphate decarboxylase. Phenolic acids also inhibited mevalonate‐5‐phosphate kinase on preincubation. The kinetics showed that p‐coumaric acid and isoferulic acid were competing with substrates, mevalonate‐5‐phosphate or mevalonate‐5‐pyre phosphate, whereas others showed an uncompetitive type of inhibition. Chlorophenoxyisobutyrate, a hypocholesterolaemic drug, had no effect on these enzymes. An improved method for the synthesis of mevalonate‐5‐phosphate and mevalonate‐5‐pyrophosphate, labeled at carbon‐1, is described. Copyright © 1979, Wiley Blackwell. All rights reserved

引用

页码：1531 / 1537

页数：7

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