DETERMINATION OF OCTAN-1-OL WATER PARTITION-COEFFICIENTS BY FLOW-INJECTION EXTRACTION WITHOUT PHASE-SEPARATION

Single-channel coaxial segmenters were used for the introduction of an aqueous or octan-1-ol solution of an organic substance directly into a continuous flow of the other solvent. The analytical signal was measured simultaneously on both aqueous and organic phase segments by an "on-tube" fast-reading spectrophotometric detector (ca. 3 ms time resolution) and treated mathematically. The octan-1-ol-water phase signal ratio corresponds to the partition coefficient of the organic substances. The applicability of the method is demonstrated by the determination of partition coefficients of phenol, citric acid, acetylsalicylic acid and sodium salicylate.