WHAT THE GRANINS TELL US ABOUT THE FORMATION OF SECRETORY GRANULES IN NEUROENDOCRINE CELLS

被引：19

作者：

CHANAT, E ^{[1
]}

PIMPLIKAR, SW ^{[1
]}

STINCHCOMBE, JC ^{[1
]}

HUTTNER, WB ^{[1
]}

机构：

[1] EUROPEAN MOLEC BIOL LAB,CELL BIOL PROGRAMME,W-6900 HEIDELBERG,GERMANY

来源：

CELL BIOPHYSICS | 1991年 / 19卷 / 1-3期

关键词：

D O I：

10.1007/BF02989882

中图分类号：

Q6 [生物物理学];

学科分类号：

071011 ;

摘要：

The biochemical properties of the granins, studied in vitro and in a perforated TGN system, support the concept that the Sciective aggregation of regulated secretory proteins, promoted by the specific lumenal milieu of the TGN, is a key step in their segregation from constitutive secretory proteins in this compartment. A recently identified membrane-associated form of the granins is likely to also be involved in this aggregation, as well as in the membrane envelopment of the aggregate during the formation of an immature secretory granule. © 1992 The Humana Press, Inc.

引用

页码：85 / 91

页数：7

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