TRANSFORMING GROWTH FACTOR-BETA-1 IS IN PLAQUES IN ALZHEIMER AND DOWN PATHOLOGIES

被引：209

作者：

VANDERWAL, EA ^{[1
]}

GOMEZPINILLA, F ^{[1
]}

COTMAN, CW ^{[1
]}

机构：

[1] UNIV CALIF IRVINE, DEPT PSYCHOBIOL, IRU BRAIN AGING, IRVINE, CA 92717 USA

来源：

NEUROREPORT | 1993年 / 4卷 / 01期

关键词：

TGF-BETA-1; BFGF; EXTRACELLULAR MATRIX; HIPPOCAMPUS; ENTORHINAL CORTEX;

D O I：

10.1097/00001756-199301000-00018

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

TRANSFORMING growth factor-beta (TGF-beta) is a major modulator of the extracellular matrix and cell growth, and shows affinity for and interaction with several substances present in plaques in Alzheimer's disease (AD). In order to examine a possible role of TGF-beta in plaque biogenesis, we studied its distribution in the limbic system of AD and Down's syndrome (DS) brains. Select plaques displayed TGF-beta1 immunoreactivity in AD and DS. TGF-beta1 plaques were mainly located in the molecular layer of the dentate gyrus in AD, while in DS TGF-beta1 plaques were preferentially located in the entorhinal cortex. In AD, TGF-beta1 immunoreactivity was also shown in neurofibrillary tangles. The presence of TGF-beta1 in plaques suggests that TGF-beta1 may play a role in the cascade of events leading to plaque formation.

引用

页码：69 / 72

页数：4

共 25 条

[1]

ASSOIAN RK, 1983, J BIOL CHEM, V258, P7155

[2] INHIBITION OF ENDOTHELIAL-CELL PROLIFERATION BY TYPE BETA-TRANSFORMING GROWTH-FACTOR - INTERACTIONS WITH ACIDIC AND BASIC FIBROBLAST GROWTH-FACTORS [J].

BAIRD, A ;

DURKIN, T .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1986, 138 (01) :476-482

[3] TRANSFORMING GROWTH-FACTOR-BETA BOUND TO SOLUBLE DERIVATIVES OF THE BETA-AMYLOID PRECURSOR PROTEIN OF ALZHEIMERS-DISEASE [J].

BODMER, S ;

PODLISNY, MB ;

SELKOE, DJ ;

HEID, I ;

FONTANA, A .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1990, 171 (02) :890-897

[4]

CHEIFETZ S, 1988, J BIOL CHEM, V263, P16984

[5]

Cotman CW, 1991, GROWTH FACTORS ALZHE, P222

[6] AGGREGATION OF THE AMYLOID PRECURSOR PROTEIN WITHIN DEGENERATING NEURONS AND DYSTROPHIC NEURITES IN ALZHEIMERS-DISEASE [J].

CUMMINGS, BJ ;

SU, JH ;

GEDDES, JW ;

VANNOSTRAND, WE ;

WAGNER, SL ;

CUNNINGHAM, DD ;

COTMAN, CW .

NEUROSCIENCE, 1992, 48 (04) :763-777

[7]

DACUNHA A, 1992, J NEUROIMMUNOL, V36, P157

[8] IMMUNODETECTION AND QUANTITATION OF THE 2 FORMS OF TRANSFORMING GROWTH FACTOR-BETA (TGF-BETA-1 AND TGF-BETA-2) SECRETED BY CELLS IN CULTURE [J].

DANIELPOUR, D ;

DART, LL ;

FLANDERS, KC ;

ROBERTS, AB ;

SPORN, MB .

JOURNAL OF CELLULAR PHYSIOLOGY, 1989, 138 (01) :79-86

[9]

DELARCO JE, 1978, P NATL ACAD SCI USA, V75, P4001

[10] SENILE PLAQUES AS ABERRANT SPROUT-STIMULATING STRUCTURES [J].

GEDDES, JW ;

ANDERSON, KJ ;

COTMAN, CW .

EXPERIMENTAL NEUROLOGY, 1986, 94 (03) :767-776

← 1 2 3 →