AN AIR-STABLE CATALYST SYSTEM FOR THE CONVERSION OF ESTERS TO ALCOHOLS

被引：117

作者：

BERK, SC ^{[1
]}

BUCHWALD, SL ^{[1
]}

机构：

[1] MIT,DEPT CHEM,CAMBRIDGE,MA 02139

来源：

JOURNAL OF ORGANIC CHEMISTRY | 1992年 / 57卷 / 14期

关键词：

D O I：

10.1021/jo00040a001

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The combination of 5 mol % of Ti(O-i-Pr)4 with 2.5-3.0 equiv of (EtO)3SiH cleanly hydrosilylates esters to silyl ethers at 40-55-degrees-C, which can be converted to the corresponding primary alcohols via aqueous alkaline hydrolysis in excellent overall yield. The reaction can be carried out in the air, without solvent, and displays a high level of functional group compatibility.

引用

页码：3751 / 3753

页数：3

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