A HIGH-RESOLUTION CYTOGENETIC MAP OF 168-COSMID DNA MARKERS FOR HUMAN CHROMOSOME-11

被引：43

作者：

HORI, TA ^{[1
]}

TAKAHASHI, E ^{[1
]}

TANIGAMI, A ^{[1
]}

TOKINO, T ^{[1
]}

NAKAMURA, Y ^{[1
]}

机构：

[1] JAPANESE FDN CANC RES,INST CANC,DIV BIOCHEM,TOKYO 170,JAPAN

来源：

GENOMICS | 1992年 / 13卷 / 01期

关键词：

D O I：

10.1016/0888-7543(92)90212-B

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

We have constructed a high-resolution cytogenetic map with 168 DNA markers, including 90 RFLP markers for human chromosome 11. The cosmid clones were mapped by fluorescence in situ suppression hybridization, in which discrete fluorescent signals can be detected directly on prometaphase R-banded chromosomes. Although these cosmid clones were distributed throughout the chromosome, they had some tendency to localize in the regions of R-positive band, such as 11p15, 11p11.2, 11q13, 11q23, and 11q25. Since these regions of chromosome 11 are considered to contain genes responsible for certain genetic diseases, cancer breakpoints involved in chromosome rearrangements, and tumor-suppressor genes, this high-resolution cytogenetic map will contribute to the molecular characterization of such genes. This map will also provide many landmarks essential for construction of the complete physical map with contigs of cosmid and YAC clones. © 1992.

引用

页码：129 / 133

页数：5

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