DIFFERENTIAL CORNEAL SENSITIVITY TO ULTRAVIOLET-LIGHT AMONG INBRED STRAINS OF MICE - CORRELATION OF ULTRAVIOLET-B SENSITIVITY WITH ALDEHYDE DEHYDROGENASE-DEFICIENCY

被引：40

作者：

DOWNES, JE ^{[1
]}

SWANN, PG ^{[1
]}

HOLMES, RS ^{[1
]}

机构：

[1] GRIFFITH UNIV,SCH SCI,NATHAN,QLD 4111,AUSTRALIA

来源：

CORNEA | 1994年 / 13卷 / 01期

关键词：

ULTRAVIOLET LIGHT; ALDEHYDE DEHYDROGENASE; ALCOHOL DEHYDROGENASE; MOUSE;

D O I：

10.1097/00003226-199401000-00011

中图分类号：

R77 [眼科学];

学科分类号：

100212 ;

摘要：

Adult male mice from four inbred albino strains (SJL/J, NZW/BL, BALB/c HeA, and SWR/J) were subjected to ultraviolet radiation (UVR) exposure (302 nm peak wavelength, intensity 398 mu W/cm(2)) for 3.25 min and photographed 4 days postexposure to assess corneal clouding. Corneal extracts from control (unexposed) mice from each strain, were also monitored for aldehyde dehydrogenase (ALDH) and alcohol dehydrogenase (ADH) activity and soluble protein content. The SWR/J strain exhibited more extensive corneal clouding after UV exposure than did the other strains, and control SWR/J mice exhibited a low activity variant phenotype for the major ocular ALDH AHD-4, and decreased levels of soluble protein in corneal extracts. These data support earlier proposals for a major role for ALDH in assisting the cornea in protecting the eye against UVR-induced damage.

引用

页码：67 / 72

页数：6