MECHANISMS OF ABSORPTION ENHANCEMENT AND TIGHT JUNCTION REGULATION

被引：148

作者：

HOCHMAN, J

ARTURSSON, P

机构：

[1] UNIV UPPSALA,CTR BIOMED,DEPT PHARM,S-75123 UPPSALA,SWEDEN

[2] MERCK & CO INC,DIV INTERX,LAWRENCE,KS 66047

来源：

JOURNAL OF CONTROLLED RELEASE | 1994年 / 29卷 / 03期

关键词：

ABSORPTION ENHANCEMENT; TIGHT JUNCTION REGULATION; EPITHELIAL PERMEABILITY; DRUG TRANSPORT; DRUG ABSORPTION; EPITHELIUM TIGHT JUNCTION PERMEABILITY;

D O I：

10.1016/0168-3659(94)90072-8

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

In this article, current knowledge on the regulation of tight junction permeability is used as a platform for an analysis of the mechanisms of some common absorption enhancers. Epithelial barriers are considered with an emphasis on the intestinal epithelium. The analysis reveal that different absorption enhancers may share some previously unrecognised characteristics but also display unique mechanisms of action.

引用

收藏

页码：253 / 267

页数：15

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