EFFECT OF PREDNISOLONE ON RENAL SCARRING IN RATS FOLLOWING INFECTION WITH SERRATIA-MARCESCENS

被引：16

作者：

HARAOKA, M

MATSUMOTO, T

MIZUNOE, Y

OGATA, N

TAKAHASHI, K

KUBO, S

TANAKA, M

KUMAZAWA, J

机构：

[1] Department of Urology Faculty of Medicine, Kyushu University Fukuoka

来源：

RENAL FAILURE | 1993年 / 15卷 / 05期

关键词：

RENAL SCARRING; S-MARCESCENS; STEROID;

D O I：

10.3109/08860229309069405

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

Renal scarring is considered a criterion of reflux nephropathy and the end stage of pyelonephritis. Prednisolone, a strong anti-inflammatory drug, at doses of 1 or 2 mg/kg prevented renal scarring in rats following infection with Serratia marcescens. Four or 8 mg/kg of prednisolone, however, did not inhibit renal scar formation. In a time course experiment, renal scarring was prevented when 4-day treatment with prednisolone was initiated 2, 5, or 13 days after infection. These results show that prednisolone is effective in preventing such scarring and suggest the clinical use of this drug for preventing renal scar formation after pyelonephritis and reflux nephropathy.

引用

页码：567 / 571

页数：5

共 9 条

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