Current Trends in Plague Research: From Genomics to Virulence

被引：30

作者：

Huang, Xiao-Zhe ^{[1
]}

Nikolich, Mikeljon P. ^{[1
]}

Lindler, Luther E. ^{[1
]}

机构：

[1] Walter Reed Army Inst Res, Dept Bacterial Dis, Div Communicable Dis & Immunol, Silver Spring, MD 20910 USA

来源：

CLINICAL MEDICINE & RESEARCH | 2006年 / 4卷 / 03期

关键词：

Genomic comparison; Virulence; Yersinia spp;

D O I：

10.3121/cmr.4.3.189

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Yersinia pestis is the causative agent of plague, which diverged from Yersinia pseudotuberculosis within the past 20,000 years. Although these two species share a high degree of homology at the DNA level (> 90%), they differ radically in their pathogenicity and transmission. In this review, we briefly outline the known virulence factors that differentiate these two species and emphasize genetic studies that have been conducted comparing Y. pestis and Y. pseudotuberculosis. These comparisons have led to a better understanding of the genetic contributions to the differences in the virulence and pathogenicity between these two organisms and have generated information that can be applied in future diagnostic and vaccine development. Comparison of the genetic differences between Y. pestis and Y. pseudotuberculosis has also lent insight into the emergence of acute pathogens from organisms causing milder diseases.

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收藏

页码：189 / 199

页数：11

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