SYNTHESIS OF OLIGONUCLEOTIDES BEARING THE NONSTANDARD BASES ISO-C AND ISO-G - COMPARISON OF ISO-C-ISO-G, C-G AND U-A BASE-PAIR STABILITIES IN RNA/DNA DUPLEXES

被引：37

作者：

ROBERTS, C ^{[1
]}

BANDARU, R ^{[1
]}

SWITZER, C ^{[1
]}

机构：

[1] UNIV CALIF RIVERSIDE,DEPT CHEM,RIVERSIDE,CA 92521

来源：

TETRAHEDRON LETTERS | 1995年 / 36卷 / 21期

关键词：

D O I：

10.1016/0040-4039(95)00603-A

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The synthesis of iso-cytidine and 2'-deoxy-iso-guanosine phosphoramidites in protected form is described. The synthesis of complementary dodecanucleotides containing a central iso-C-iso-G base-pair was achieved. It is found that the iso-C-iso-G base-pair has comparable stability to a C-G base-pair.

引用

页码：3601 / 3604

页数：4

共 16 条

[1] RIBOSOME-MEDIATED INCORPORATION OF A NONSTANDARD AMINO-ACID INTO A PEPTIDE THROUGH EXPANSION OF THE GENETIC-CODE
BAIN, JD
SWITZER, C
CHAMBERLIN, AR
BENNER, SA
[J]. NATURE, 1992, 356 (6369) : 537 - 539
[2] ZWITTERIONIC DNA
HASHIMOTO, H
NELSON, MG
SWITZER, C
[J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1993, 115 (16) : 7128 - 7134
[3] SYNTHESIS OF A DODECARIBONUCLEOTIDE, GUAUCAAUAAUG, BY USE OF FULLY PROTECTED RIBONUCLEOTIDE BUILDING-BLOCKS
KAMIMURA, T
TSUCHIYA, M
URAKAMI, K
KOURA, K
SEKINE, M
SHINOZAKI, K
MIURA, K
HATA, T
[J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1984, 106 (16) : 4552 - 4557
[4] 2'-DEOXYISOGUANOSINE AND BASE-MODIFIED ANALOGS - CHEMICAL AND PHOTOCHEMICAL-SYNTHESIS
KAZIMIERCZUK, Z
MERTENS, R
KAWCZYNSKI, W
SEELA, F
[J]. HELVETICA CHIMICA ACTA, 1991, 74 (08) : 1742 - 1748
[5] DNA-RNA HYBRID DUPLEXES CONTAINING OLIGO(DA-RU) SEQUENCES ARE EXCEPTIONALLY UNSTABLE AND MAY FACILITATE TERMINATION OF TRANSCRIPTION
MARTIN, FH
TINOCO, I
[J]. NUCLEIC ACIDS RESEARCH, 1980, 8 (10) : 2295 - 2299
[6] AMIDINE PROTECTING GROUPS FOR OLIGONUCLEOTIDE SYNTHESIS .16.
MCBRIDE, LJ
KIERZEK, R
BEAUCAGE, SL
CARUTHERS, MH
[J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1986, 108 (08) : 2040 - 2048
[7] SEQUENCE-SPECIFIC THERMODYNAMIC AND STRUCTURAL-PROPERTIES FOR DNA-CENTER-DOT-RNA DUPLEXES
RATMEYER, L
VINAYAK, R
ZHONG, YY
ZON, G
WILSON, WD
[J]. BIOCHEMISTRY, 1994, 33 (17) : 5298 - 5304
[8] Rich A., 1962, HORIZONS BIOCH, P103
[9] STABILITY AND PROPERTIES OF DOUBLE AND TRIPLE HELICES - DRAMATIC EFFECTS OF RNA OR DNA BACKBONE COMPOSITION
ROBERTS, RW
CROTHERS, DM
[J]. SCIENCE, 1992, 258 (5087) : 1463 - 1466
[10] FACILE SYNTHESIS OF 2'-DEOXYISOGUANOSINE AND RELATED 2',3'-DIDEOXYRIBONUCLEOSIDES
SEELA, F
GABLER, B
[J]. HELVETICA CHIMICA ACTA, 1994, 77 (03) : 622 - 630

← 1 2 →