USE OF METHYLPHENIDATE IN THE TREATMENT OF CHILDREN WITH AUTISTIC DISORDER

被引：140

作者：

QUINTANA, H ^{[1
]}

BIRMAHER, B ^{[1
]}

STEDGE, D ^{[1
]}

LENNON, S ^{[1
]}

FREED, J ^{[1
]}

BRIDGE, J ^{[1
]}

GREENHILL, L ^{[1
]}

机构：

[1] NEW YORK STATE PSYCHIAT INST & HOSP,NEW YORK,NY 10032

来源：

JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS | 1995年 / 25卷 / 03期

关键词：

D O I：

10.1007/BF02179289

中图分类号：

B844 [发展心理学（人类心理学）];

学科分类号：

040202 ;

摘要：

The use of psychostimulants in autistic disorder has not received extensive evaluation. Furthermore, their use for the symptomatic control of autistic disorder has been felt to be contraindicated. This study investigates the use of methylphenidate (MPH) for the treatment of selected symptoms of autistic disorder. Ten children, ages 7-11, with a DSM-III-R diagnosis of autistic disorder participated in a double-blind crossover study using placebo and two MPH doses (10 mg or 20 mg bid). Subjects showed modest but statistically significant improvement on MPH over placebo. No significant side effects including worsening stereotypic movements occurred on either dose. Improvement in hyperactivity and lack of adverse effects suggest that MPH may be useful in the treatment of hyperactive autistic children.

引用

页码：283 / 294

页数：12

共 35 条

[1]

AMAN M, 1988, AM ACADEMY CHILD ADO, V27, P821

[2]

AMAN MG, 1985, PSYCHOPHARMACOL BULL, V21, P845

[3]

American Psychiatric Association, 1987, DIAGNOSTIC STAT MANU, V3rd

[4]

American Psychiatric Association, 1980, DIAGN STAT MAN MENT, V3rd

[5]

American Psychiatric Association, 1968, DIAGN STAT MAN MENT, V2

[6]

ANDERSON LT, 1984, AM J PSYCHIAT, V141, P1195

[7] THE EFFECTS OF HALOPERIDOL ON DISCRIMINATION-LEARNING AND BEHAVIORAL SYMPTOMS IN AUTISTIC-CHILDREN [J].

ANDERSON, LT ;

CAMPBELL, M ;

ADAMS, P ;

SMALL, AM ;

PERRY, R ;

SHELL, J .

JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS, 1989, 19 (02) :227-239

[8]

BARKLEY RA, 1991, PEDIATRICS, V87, P519

[9] METHYLPHENIDATE TREATMENT OF HYPERACTIVE AUTISTIC-CHILDREN [J].

BIRMAHER, B ;

QUINTANA, H ;

GREENHILL, LL .

JOURNAL OF THE AMERICAN ACADEMY OF CHILD AND ADOLESCENT PSYCHIATRY, 1988, 27 (02) :248-251

[10] RESPONSE TO TRIIODOTHYRONINE AND DEXTROAMPHETAMINE - STUDY OF PRESCHOOL SCHIZOPHRENIC CHILDREN [J].

CAMPBELL, M ;

FISH, B ;

DAVID, R ;

SHAPIRO, T ;

COLLINS, P ;

KOH, C .

JOURNAL OF AUTISM AND CHILDHOOD SCHIZOPHRENIA, 1972, 2 (04) :343-358

← 1 2 3 4 →